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Muharrem Akcan

Prof. Dr. Muharrem Akcan

Fen Edebiyat Fakültesi

Yayınlar

  Yıllara Göre Grafiklerim Türlere Göre Grafiklerim Kapsamına Göre Grafiklerim Endeksine Göre Grafiklerim

Kitaplar

Akcan, M. & Craık, D. J. (2015). Venoms to Drugs Venom as a Source for the Development of Human Therapeutics, Cambridge: Royal Society of Chemistry

Özet Metin

Anahtar Kelimeler

Akcan, M. & Craık, D. J. (2013). Peptide Synthesis and Applications, New York: Humana Press

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Akcan, M. & Craik, D. J. (2011). Peptide Drug Discovery and Development Translational Research in Academia and Industry, Weinheim: Wiley-VCH Verlag GmbH Co. KGaA

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Makaleler

Kara, Ş., , A. D. E., , Ç. U. S. &, A. M. (2023). Enhancing the Stability of Tumor Homing LyP-1 Peptide Using Cyclization and Retro Grafting Strategies. International Journal of Peptide Research and Therapeutics, 29(),30 - . 10.1007/s10989-023-10504-7

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Kara, Ş., , K. C. &, A. M. (2022). Design and modification of frog skin peptide brevinin-1GHa with enhanced antimicrobial activity on Gram-positive bacterial strains. Amino Acids, 54(9),1327 - 1336. 10.1007/s00726-022-03189-7

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Baş, E. B., , K. C., , K. O. M. &, A. M. (2022). Cyclotide-rich fractions containing nanofibers by electrospinning: preparation, characterization and examination of antimicrobial activity. Turkish Journal of Chemistry, 46(5),1651 - 1660. 10.55730/1300-0527.3468

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Turan, K., , A. M. &, K. O. M. (2021). Preparation, characterization and antibacterial activity of Malva Sylvestris L. seed extract containing novel electrospun PVA nanofibers. GAZI UNIVERSITY JOURNAL OF SCIENCE, 34(4),987 - 998. 10.35378/gujs.794638

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Akcan, M., Clark, R. J., Daly, N. L., Conibear, A. C., De, F. A., Heghinian, M. D., Sahil, T., Adams, D. J., Mari, F. & Craik, D. J. (2015). Transforming conotoxins into cyclotides backbone cyclization of P superfamily conotoxins. Biopolymers: Peptide Science, 104(6),682 - 692. 10.1002/bip.22699

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De, V. S. J., Swedberg, J. E., Akcan, M., Rosengren, K. J., Brattsand, M., Craik, D. J. & Harris, J. M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor 1 SFTI 1 provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469(2),243 - 253. 10.1042/BJ20150412

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Yu, R., Seymour, V. A. L., Berecki, G., Jia, X., Akcan, M., Adams, D. J., Kaas, Q. & Craik, D. J. (2015). Less is More Design of a Highly Stable Disulfide Deleted Mutant of Analgesic Cyclic alpha Conotoxin Vc1 1. Scientific Reports, 5(13264),1 - 11. 10.1038/srep13264

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Schroeder, C. I., Swedberg, J. E., Withka, J. M., Rosengren, K. J., Akcan, M., Clayton, D. J., Daly, N. L., Cheneval, O., Borzilleri, K. A., Griffor, M., Stock, I., Colless, B., Walsh, P., Sunderland, P., Reyes, A., Dullea, R., Ammirati, M., Liu, S., Mcclure, K. F., Tu, M., Bhattacharya, S. K., Liras, S., Price, D. A. & Craik, D. J. (2014). Design and Synthesis of Truncated EGF A Peptides that Restore LDL R Recycling in the Presence of PCSK9 In Vitro. Chemistry & Biology, 21(2),284 - 294. 10.1016/j.chembiol.2013.11.014

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Koehbach, J., O‘Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A. G., Daly, N. L., Harvey, P. J., Arrowsmith, S., Gunasekera, S., Smith, T. J., Wray, S., Goransson, U., Dawson, P. E., Craik, D. J., Freissmuth, M. & Gruber, C. W. (2013). Oxytocic plant cyclotides as templates for peptide G protein coupled receptor ligand design. Proceedings of the National Academy of Sciences, 110(52),21183 - 21188. 10.1073/pnas.1311183110

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Luo, S., Zhangsun, D., Zhu, X., Wu, Y., Hu, Y., Christensen, S., Harvey, P. J., Akcan, M., Craik, D. J. & Mcıntosh, J. M. (2013). Characterization of a Novel alpha Conotoxin TxID from Conus textile That Potently Blocks Rat alpha3beta4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry, 56(23),9655 - 9663. 10.1021/jm401254c

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Luo, S., Zhangsun, D., Wu, Y., Zhu, X., Hu, Y., Mcıntyre, M., Christensen, S., Akcan, M., Craik, D. J. & Mcıntosh, J. M. (2013). Characterization of a Novel alpha Conotoxin from Conus textile That Selectively Targets alpha6 alpha3beta2beta3 Nicotinic Acetylcholine Receptors. Journal of Biological Chemistry, 288(2),894 - 902. 10.1074/jbc.M112.427898

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Akcan, M., Cao, Y., Chongxu, F. & Craik, D. J. (2013). The three dimensional solution structure of mini M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorganic Medicinal Chemistry, 21(12),3590 - 3596. 10.1016/j.bmc.2013.02.012

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Clark, R. J., Akcan, M., Kaas, Q., Daly, N. L. & Craik, D. J. (2012). Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59(4),446 - 455. 10.1016/j.toxicon.2010.12.003

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Akcan, M., Stroud, M. R., Hansen, S. J., Clark, R. J., Daly, N. L., Craik, D. J. & Olson, J. M. (2011). Chemical Re engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy. Journal of Medicinal Chemistry, 54(3),782 - 787. 10.1021/jm101018r

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Dürüst, Y., Akcan, M., Olli, M., Elina, S. & Kalevi, P. (2008). Synthesis of new thiophene furan and pyridine substituted 1 2 4 5 oxadiazaboroles. Polyhedron, 27(3),999 - 1007. 10.1016/j.poly.2007.11.043

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Dürüst, Y., Dürüst, N. & Akcan, M. (2007). Potentiometric Study of Acid Base Equilibria of 3 5 Disubstituted 1 2 4 5 Oxadiazaboroles in Nonaqueous Media. Journal of Chemical & Engineering Data, 52(3),718 - 720. 10.1021/je0604683

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Kara, Ş. & Akcan, M. (2020). Disulfide-rich peptides in drug development. Hacettepe Journal of Biology and Chemistry, 48(3),219 - 229. https://doi.org/10.15671/hjbc.658764

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Bildiriler

Akcan, M. & Kara, Ş. (2019). Peptide Based Drug Design, Euroasian Congress on Molecular Biotechnology, 19.09.2019

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Biyoteknoloji

Çetin, B., Akcan, M. & Özen, T. E. (2018). Secondary metabolite studies of wild and micropropagated Taraxacum officinale Linn., 7th International Molecular Biology and Biotechnology Congress, 25.04.2018

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Kara, Ş. & Akcan, M. (2018). Lenf Tümörleri ile İlişkili LyP-1 Peptidinin Modifikasyonu, Uluslararası Katılımlı 6. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi, 22.03.2018

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Kara, Ş. & Akcan, M. (2017). Grafting of a Cancer Targeting Peptide Epitope onto Cyclotides, 5th International BAU Drug Design Congress, 19.10.2017

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Çetin, B. & Akcan, M. (2017). İn Vitro Doku ve Klasik Kültür ile Üretilen Prunella Vulgaris L. Bitkilerindeki Metabolitlerin LC-MS ile Analizi, 19. Uluslararası Katılımlı Ulusal Biyoteknoloji Kongresi, 01.12.2017

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Karaoğlu, Ş. & Akcan, M. (2016). Kanser Hücrelerini Hedefleyen Peptid Bazlı İlaç Adaylarının Sentezi ve Simule Edilmiş Mide Sıvısı İçerisindeki Kararlılıklarının İncelenmesi, 4. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi,Üretimi ve Standardizasyonu Kongresi, 17.03.2016

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Akcan, M. (2015). Peptid Yapılı İlaç Adayları ve Nükleer Manyetik Rezonans Spektroskopisi, 3.İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi, 20.03.2015

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Karaoğlu, Ş. & Akcan, M. (2015). Reengineering of Trypsin Inhibitor Peptide SFTI 1 for Cancer Targeting, 3rd BAU Drug Design Congress, 01.09.2015

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Karaoğlu, Ş. & Akcan, M. (2015). Enhancing the Stability of Peptides that Targets Tumor Associated Carbonic Anhydrase IX, EACR-Sponsored 3rd Anticancer Agent Development Congress, 18.05.2015

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Akcan, M., Stroud, M. R., Hansen, S. J., Clark, R. J., Daly, N. L., Craik, D. J. & Olson, J. (2014). Peptid bazlı ilaçların tasarım ve sentezi, 2.İlaç Kimyası, Üretimi, Teknolojisi ve Standardizasyonu Kongresi, 21.03.2014

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Swedberg, J. E., De, V. S. J., Akcan, M., Rosengren, J. K., Craik, D. J. & Harris, J. M. (2013). Using the SFTI scaffold to deconstruct and redirect the Laskowski mechanism of protease inhibition, The 10th Australian Peptide Conference, 08.09.2013

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Koehbach, J., Obrien, M., Akcan, M., Craik, D. J., Muttenthaler, M. & Gruber, C. W. (2013). Exploring bioactive peptides as pharmacological tools for oxytocin and vasopressin ligand design, The 10th Australian Peptide Conference, 08.09.2013

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Koehbach, J., Obrien, M., Miazzo, M., Muttenthaler, M., Akcan, M., Smith, T. J., Craik, D. J., Freissmuth, M. & Gruber, C. W. (2012). Pharmacological characterization of circular plant peptides with oxytocin like activity, 32nd European Peptide Symposium "Peptides 2012", 02.09.2012

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Akcan, M., Clark, R., Daly, N. L., De, F. A., Heghinian, M., Adams, D. J., Mari, F. & Craik, D. J. (2012). Transforming conotoxins into cyclotides backbone cyclization of P superfamily conotoxins, 2nd International Conference on Circular Proteins, 14.10.2012

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Koehbach, J., Obrien, M., Muttenthaler, M., Akcan, M., Craik, D. J., Freissmuth, M. & Gruber, C. W. (2012). Natural circular peptides as pharmacological tools to study oxytocin and vasopressin receptor signaling, 2nd International Conference on Circular Proteins, 14.10.2012

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Craik, D. J., Akcan, M., Stroud, M. R., Hansen, S., Clark, R. J., Daly, N. L., Olson, J., Callaghan, B. & Adams, D. (2011). Running rings around toxins, Fourth Conference on Venoms to Drugs, 15.05.2011

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Craik, D. J., Poth, A., Colgrave, M., Akcan, M., Oku, B., Chan, A. & Daly, N. L. (2011). Discovery and applications of naturally occurring cyclic peptides, 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 04.09.2011

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Akcan, M., Stroud, M. R., Hansen, S. A., Clark, R. J., Daly, N. L., Craik, D. J. & Olson, J. (2009). Tumor Paint A Scorpion Toxin Peptide That Targets Fluorescent Dye to Brain Tumor Cells for Real Time Intraoperative Imaging, Joint Meeting of the Society for Neuro Oncology/American Association of Neurological Surgeons/Congress of Neurological Surgeons, 22.10.2009

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Akcan, M., Clark, R., Daly, N. L., Meunier, F. & Craik, D. J. (2009). Chemical modification of omega conotoxins Backbone cyclization of omega conotoxin MVIIA, 1st International Conference on Circular Proteins, 18.10.2009

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